Coronary physiology, which includes indexes for the assessment of epicardial vessels and microcirculation, has been introduced and validated to support physicians in their daily clinical decision-making for patients with coronary artery disease.

Despite numerous randomized clinical studies and high levels of recommendation in both European and American guidelines, the integration of coronary physiology into everyday clinical practice remains limited.

Trying to overcome the common barriers in the implementation of coronary physiology, many Italian colleagues originated the #FullPhysiology initiative.

The #FullPhysiology approach consists of a systematic step-by-step assessment of each component of the coronary circulation, including epicardial, microvascular, and vasomotor function.

#FullPhysiology is:

• A daily practice mindset
• Scientific documents
• X account @FullPhysiol
• Scientific events
• A network of Italian centers sharing experience and methodology